Supports Nervous System Health*
PRODUCT DISCUSSION
PhysioLogics 5-HTP 100 mg provides L-5-Hydroxytryptophan (5-HTP) along with the
B Vitamins Niacin and Vitamin B6 and the herb Valerian to promote nervous system
health.* 5-HTP is not present in significant amounts in the typical diet and is
derived from the seeds of Griffonia simplicifolia, a plant of West African
origin.
STRUCTURE AND FUNCTION
The compound 5-HTP is a precursor to serotonin, a neurotransmitter involved in
sending messages through the brain and nervous system.* It supports a calm,
relaxed mood and promotes feelings of well-being.*
Niacin (B-3), also known as nicotinic acid and nicotinamide, helps maintain a healthy nervous system.* The major coenzyme forms of Vitamin B-6 are Pyridoxine (B-6), pyridoxal 5'-phosphate (PLP), and pyridoxamine (PMP). Vitamin B-6 supports brain and nervous system health.*
Valerian and its principle components have been extensively studied for well over 50 years. Lab data indicates that valerenic acid and acetylvalerenic acid in valerian can inhibit GABA transaminase, thereby prolonging the effects of GABA on sedation in the central nervous system. L-hydroxypinoresinol, another natural valerian alkaloid, has been found to possess a high affinity for the 5-HT1A receptor, which could also play a role in Valerian's beneficial effects.
CLINICAL EVIDENCE
- In this study, 24 subjects received a one-time dose of 200 mg 5-hydroxytryptophan (5-HTP) or placebo in a double-blinded trial. The subjects receiving 5-HTP experienced a significantly calmer mood than the placebo group, supporting the use of 5-HTP for feelings of well-being. (Schruers et al, 2002)
- A total of 34 subjects were given either 200 mg of 5-HTP or placebo in a double-blinded clinical trial. The results showed a significant positive effect on feelings of calmness and well-being in the female subjects compared with placebo. (Maron et al, 2004)
SUMMARY PhysioLogics 5-HTP provides a unique combination of several compounds that have effects on feelings of well-being, as well as brain and nervous system health.*
SUGGESTED DOSAGE For adults, take one (1) capsule twice daily as needed or before bedtime, or follow the advice of a health professional.
WARNING: Not for use by pregnant or lactating women. Patients with heart problems or who are taking antidepressants or weight-control drugs should avoid this product. May cause drowsiness: Patients should not drive a motor vehicle or operate heavy machinery while using this product.
REFERENCES
Maron E, Tõru I, Vasar V, Shlik J. The effect of 5hydroxytryptophan on
cholecystokinin-4-induced panic attacks in healthy volunteers. J
Psychopharmacol. 2004;18:194-9.
Schruers K, van Diest R, Overbeek T, Griez E. Acute L-5hydroxytryptophan administration inhibits carbon dioxideinduced panic in panic disorder patients. Psychiatry Res. 2002;113:237-43
Upton, R., Valerian root Valeriana officinalis, Analytical, Quality Control, and Therapeutic Monograph, in American Herbal Pharmacopoeia and Therapeutic Compendium. 1999. Santa Cruz, CA.
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