Alpha Lipoic Acid 300mg 30 vsoftgels - Physiologics

PRODUCT ALSO KNOWN AS
Thioctic Acid, 1,2-dithiolane-3-pentanoic acid, 1,2-dithiolane-3 valeric acid, 6,8-thioctic acid

PRODUCT DISCUSSION
Alpha Lipoic Acid 300 mg from PhysioLogics provides this remarkable universal antioxidant that recycles Glutathione, Vitamins C and E, and Coenzyme Q10, and supports sugar metabolism at dosages of 600 mg per day. This product can be used as part of your diet to help maintain a healthy blood sugar level.*

STRUCTURE AND FUNCTION
The metabolic role of Alpha Lipoic Acid as a cofactor in the multi-enzyme oxidative decarboxylation complexes of the Krebs citric acid cycle has been established for decades. The Krebs cycle is a major biochemical process that derives energy from carbohydrates. Pyruvate dehydrogenase and a-ketogluterate dehydrogenase are two central enzyme complexes that require Alpha Lipoic Acid as a coenzyme for glucose metabolism and the Krebs cycle. Pyruvate dehydrogenase complex (PDC) converts pyruvate to acetyl-CoA, one of the two essential substrates needed to produce citrate. A deficiency in this enzymatic complex may limit the production of citrate. Because citrate is the first substrate in the Krebs cycle, the process cannot proceed. Alternate metabolic pathways may be stimulated in an attempt to produce acetyl-CoA; however, an energy deficit remains, especially in the central nervous system.*

More recently, Alpha Lipoic Acid has received attention for its role as a "universal antioxidant." Possessing the ability to neutralize free radicals in both the aqueous and lipid phases of the cell, Alpha Lipoic Acid scavenges hydroxyl radicals, hydrogen peroxide, peroxynitrite, hypochlorous acid, singlet oxygen and nitric oxide. In addition, it regenerates NAD+ from NADH as well as intracellular levels of Glutathione, Vitamins C and E, and Coenzyme Q10, effectively helping to establish a cellular antioxidant network. As an antioxidant enhancer, Alpha Lipoic Acid works to support against oxidative stress.*

INDICATIONS
Alpha Lipoic Acid works to support against oxidative stress. In addition to its role as an antioxidant enhancer, Alpha Lipoic Acid is intended for your clients that want to maintain a healthy blood sugar level already within the normal range.*

HOW CLIENTS MAY BENEFIT

• Alpha Lipoic Acid helps metabolize sugar in the body.*
• Involved in glucose transport.*
• Promotes cellular energy production.*
• Recycles intracellular Vitamin C and E, Coenzyme Q10 and Glutathione.*
• Superior antioxidant support.*

SCIENTIFIC RESEARCH

• In order to investigate the antioxidant support of Alpha Lipoic Acid, Marangon et al., conducted study in which plasma, cholesterol and urine oxidizability were measured before and after 4 months of 600 mg/day Alpha Lipoic Acid supplementation. Compared to base line samples, Alpha Lipoic Acid significantly promoted the lag time of oxidation of plasma and cholesterol oxidation, and supported fewer isoprostanes in the urine, markers of oxidative stress.*
• Jacob et al., evaluated the effects of 600 mg Alpha Lipoic Acid in a placebo-controlled double-blind study of 74 subjects. All subjects were comparable at base line. Following 4 weeks of supplementation, significantly more subjects experienced an increase in sensitivity to sugar-metabolizing hormone when compared to placebo, as measured by an isoglycemic glucose-clamp.*

SUMMARY
Alpha Lipoic Acid has steadily been receiving greater attention as an extraordinary supplement, providing comprehensive antioxidant support against oxidative stress. As an integral part of the Krebs cycle, Alpha Lipoic Acid works to metabolize glucose into cellular energy.*

SUGGESTED DOSAGE
For adults, take one (1) capsule twice daily, preferably with a meal, or follow the advice of your health care professional. As a reminder, discuss the supplements and medications you take with your health care providers.

REFERENCES
Borcea, V., et al. Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. Free Radical Bio & Med. 1999. 26(11-12): 1495-1500.

Bustamante, J., et al. Lipoic acid in liver metabolism and disease. Free Radical Bio & Med. 1998. 24(6): 1023-1039.

Jacob, S., et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic Biol Med. 1999 Aug;27(3-4):309-14.

Jacob, S. Oral administration of RAC-alpha lipoic acid modulates insulin sensitivity in patients with Type 2 diabetes mellitus a placebo controlled pilot trial. Free Radical Bio & Med. 1999. 27(3-4): 309-314.

Konrad, T., et al. Alpha lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 Diabetes. Diabetes care. 1999. 22(2): 280-287.

Marangon K, et al. Comparison of the effect of alphalipoic acid and alpha-tocopherol supplementation on measures of oxidative stress. Free Radic Biol Med. 1999 Nov;27(9-10):1114-21.

Packer, L. et al. Alpha-lipoic acid as a biological antioxidant. Free Radical Bio & Med. 1995. 19 (2) 227-250.

Ruhnaut, K.J., et al. Effects of 3 week oral treatment with the antioxidant thioctic acid (lipoic acid) in symptomatic diabetic polyneuropathy. Diabetic Med: J Brit Diabetic Assoc. 1999. 16(12): 1040-1043.

Wagh, S S. Mode of action of lipoic acid in diabetes. J Biosci. 1987. Mar. 159-74. vol.11

 

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