Lubricates Joints to Promote Comfort & Flexibility*
PRODUCT IS A SYNERGISTIC
MIXTURE OF
Glucosamine Sulfate, Chondroitin Sulfate, MSM (Methylsulfonylmethane), Vitamin C
(Ascorbic Acid), Vitamin E (d-Alpha Tocopheryl Acetate), Manganese (Manganese
Aspartate), Evening Primrose Oil, Flaxseed Oil, Fish Oil
PRODUCT DISCUSSION
Cartilage Companion® + from PhysioLogics contains the three most popular
supplements to support joint health, plus essential and non-essential
polyunsaturated Omega fatty acids. Glucosamine and Chondroitin Sulfate are key
structural components of cartilage and play a role in the maintenance of joints.
MSM is an organic source of sulfur, one of the major building blocks of
glucosaminoglycans.*
STRUCTURE AND FUNCTION
Cartilage is associated with an extracellular matrix composed of
glycosaminoglycans (GAGs) and proteoglycans, which interact with collagen and
elastic fibers to cushion joints and provide range of motion. GAGs are long,
unbranched polysaccharide chains composed of repeating disaccharide units.
Proteoglycans are proteins that carry one or more GAG side chains, and help bind
components of cartilage together.
Glucosamine, a key component of cartilage, is an aminomonosaccharide utilized in the synthesis of GAGs and proteoglycans. Glucosamine from food and supplements is incorporated into the metabolic pathway of proteoglycan and GAG synthesis, promoting cartilage production and articular function.*
Chondroitin is also a natural constituent of cartilage, made up of repeating chains of GAGs. By promoting water retention, proteoglycan and GAG synthesis, and healthy enzymatic metabolism of cartilage, Chondroitin supports joint flexibility and function.*
MSM supplies an organic source of sulfur. Sulfur is used in the body as a constituent of certain amino acids, collagen and disulfide bonds, and provides a raw material for the production of GAGs and collagen, making MSM an important part of cartilage and joint maintenance.*
INDICATIONS
For your clients who are weekend athletes or maturing adults, Cartilage
Companion® + provides Glucosamine, Chondroitin and MSM, the three leading
ingredients to support joint and cartilage maintenance and promote range of
motion. This product also provides all three Omega polyunsaturated fatty acids
for additional health benefits.*
HOW CLIENTS MAY BENEFIT
- Supports cartilage maintenance.*
- Promotes range of motion.*
- Glucosamine and Chondroitin Sulfate supply natural components of cartilage.*
- Glucosamine and Chondroitin Sulfate promote proteoglycan and GAG synthesis.*
- Chondroitin promotes water retention and healthy enzymatic metabolism of cartilage.*
- MSM provides sulfur, a raw material for GAG and collagen synthesis.*
SCIENTIFIC RESEARCH
- The Lancet published a double-blind placebo-controlled study that investigated the long-term effects of Glucosamine sulphate in a trial of 212 subjects. After 3 years of 1500 mg/day, the subjects that received Glucosamine maintained cartilage as measured in the knee. Joint support was not observed in the placebo group.
- Another double-blind study observed that subjects given 1500 mg Glucosamine sulfate per day experienced 50% more joint support after 3 weeks and 72% more support after 30 days, while those with placebo reported only 36% more joint support after 30 days.
SUMMARY
Cartilage Companion® + provides the three leading ingredients to support joint
and cartilage health. Glucosamine and Chondroitin Sulfate are key structural
components of cartilage and play an important role in the maintenance of joint
cartilage. MSM provides an organic source of sulfur, one of the raw materials of
GAGs and collagen. These ingredients work synergistically to support joint
health and promote range of motion. In addition, this product provides a source
of Omega-3, Omega-6, and Omega-9 polyunsaturated fatty acids.*
SUGGESTED DOSAGE
For adults, take one (1) softgel three times daily, preferably with a meal or
follow the advice of your health care professional. As a reminder, discuss the
supplements and medications you take with your health care providers.
REFERENCES
Barclay, T.S. et al. Glucosamine. The Annals of Pharmacotherapy. 1998. 32(5);
May: 574-579.
De Camara, C.C., et al. Glucosamine sulfate for osteoarthritis. Annals of Pharmacotherapy. 1998.
Deal, CL. et al. Nutraceuticals as therapeutic agents in osteoarthritis; The role of Glucosamine, Chondroitin Sulfate, and Collagen Hydrolysate. Rheum Dis Clin North Am. 1999. 25(2); May: 379-395.
Drovanti, A. et al. Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: A placebo-controlled double-blind investigation. Clinical Therapeutics. 1980. 3: 260-272.
Reginster, J.Y. et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. The Lancet. 2001. 357(9); Jan 27: 251-256.
Sizer, F. et al. Water and minerals: chloride and sulfur. Nutrition: Concepts and Controversies. 7th ed. 1997. Wadsworth Publishing Co. Albany, NY. 303.
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