Red Yeast Rice with Co Q-10 60 Softgels - Physiologics

Supports Heart Health*
Promotes Energy Production

HOW PATIENTS MAY BENEFIT

• Supports cellular levels of ATP, the energy source for all biological processes*

PRODUCT DISCUSSION
Red Yeast Rice has been a part of the traditional Chinese diet for centuries. It is created by fermenting cooked rice with Monascus purpureus yeast at carefully controlled temperatures. Red yeast rice contains natural pigments, starch, fatty acids, phytosterols and isoflavones along with a group of fungal metabolites. Red yeast rice supports overall health benefits.*

Coenzyme Q-10 is an essential component of the mitochondrial electron transport chain that produces adenosine triphosphate (ATP), the energy source for virtually every cellular process.* It is a powerful antioxidant and also supports heart health.* The body's Co Q-10 may diminish with age, strenuous exercise, and environmental stressors. In addition, certain regularly prescribed drugs may cause Co Q-10 depletions.**

STRUCTURE AND FUNCTION
Coenzyme Q-10 is naturally found in the inner mitochondrial membrane of every cell in the human body and plays a fundamental role in the production of ATP. It accepts electrons for mitochondrial complex I and complex II, and donates electrons to complex III during oxidative phosphorylation. Each pair of electrons in the electron transport chain must interact with Co Q-10, the rate-limiting component of the mitochondrial respiratory cycle.

In its reduced form, Co Q-10 is a lipid-soluble antioxidant that helps neutralize potentially damaging superoxide and lipid radicals.* Co Q-10 scavenges reactive oxygen species to support the cell during oxidative stress that can lead to cell and DNA damage.*

In addition, Co Q-10 supports the normal physiology of the heart and promotes healthy circulation through heart tissue.* It stabilizes calcium-dependent ion channels in heart tissue to prevent depletion of molecules essential for ATP synthesis.*

CLINICAL EVIDENCE

• In one double-blind trial, researchers administered daily doses of 100 mg of Co Q-10 to 80 patients for 17 weeks. Eighty-nine percent experienced support of cardiovascular function, respiratory function and muscle strength support. These benefits lasted during the entire course of treatment. (Tran et al, 2001)
• In a double-blind, placebo-controlled, randomized study conducted by Berman et al, patients with end-stage heart failure were provided with 60 mg Co Q-10 or placebo daily. Patients taking Co Q-10 showed significant improvement in a 6-min walk test, dyspnea, fatigue and New York Heart Association (NYHA) functional class for stages of heart failure. Thus, Coenzyme Q-10 was shown to effectively support overall well being including heart health. (Berman et al, 2004)

SUMMARY
This product combines Red Yeast Rice to support overall health with Coenzyme Q-10 for ATP production, maintenance of heart health, and antioxidant support.*
**Coenzyme Q-10 is not intended to serve as a replacement for any prescribed drugs, nor should you discontinue taking any prescribed medications while supplementing with Coenzyme Q-10.

SUGGESTED DOSAGE
For adults, take one (1) softgel daily, preferably with meals, or follow the advice of your health care professional.

REFERENCES
Berman, M. et al. Coenzyme Q-10 in patients with endstage heart failure awaiting cardiac transplantation: A randomized, placebo-controlled study. Clin Cardiol. 2004;27:295-9.

Cheng H. Oxidized LDL, diet, and natural antibodies. Am J Clin Nutr 1999;70:104-13.

Folkers K. Relevance of the biosynthesis of coenzyme Q-10 and the four bases of DNA as a rationale for the molecular causes of cancer and a therapy. Biochem Biophys Res Commun. 1996;224:358-61.

Frei B, Kim MC, Ames BN. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci USA. 1990;87:4879-83.

Greenberg S, Frishman WH. Co-enzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol. 1990;30:596-608.

Kato T, Yoneda S, Kako T, et al. Reduction in blood viscosity by treatment with coenzyme Q-10 in patients with ischemic heart disease. Int J Clin Pharmacol Ther Toxicol. 1990;28:123-6.

Langsjoen H, Langsjoen P, Langsjoen P, et al. Usefulness of coenzyme Q-10 in clinical cardiology: a long-term study. Mol Aspects Med. 1994;15 Suppl:s165-75.

Mellors A, Tappel AL. The inhibition of mitochondrial peroxidation by ubiquinone and ubiquinol. J Biol Chem. 1966;241:4353-6.

Mortensen SA, Vadhanavikit S, Muratsu K, Folkers K. Coenzyme Q10: clinical benefits with biochemical correlates suggesting a scientific breakthrough in the management of chronic heart failure. Int J Tissue React. 1990;12:155-62.

Nohl H, Gille L, Staniek K. The biochemical, pathophysiological, and medical aspects of ubiquinone function. Ann NY Acad Sci. 1998;854:394-409.

Overvad K, Diamant B, Holm L, et al. Coenzyme Q-10 in health and disease. Eur J Clin Nutr. 1999;53:764-70.

Rauchova H, Drahota Z, Lenaz G. Function of coenzyme Q in the cell: some biochemical and physiological properties. Physiol Res. 1995;44:209-16.

Reis F, Hermida RC, Souza I, et al. Circadian and seasonal variation of endogenous ubiquinone plasma level. Chronobiol Int. 2002;19:599-614.

Tran MT, Mitchell TM, Kennedy DT, Giles JT. Role of coenzyme Q-10 in chronic heart failure, angina, and hypertension. Pharmacotherapy. 2001;21:797-806.

Weber C, Jakobsen TS, Mortensen SA, et al. Effect of dietary coenzyme Q-10 as an antioxidant in human plasma. Mol Aspects Med. 1994;15 Suppl:s97-102.

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