Scientifically Formulated to Support a Healthy Body Composition*
HOW PATIENTS MAY BENEFIT
- Use with a reduced calorie diet and regular exercise program
- Helps support metabolism of dietary lipids, carbohydrates, and proteins for patients with diverse eating patterns and meal compositions*
PRODUCT DISCUSSION
PhysioLogics Tonalin® CLA provides multi-level diet support by working through
distinct enzymatic and metabolic pathways. The patented, active ingredients have
been used in a variety of in-vivo human trials. This product has been
scientifically formulated to help support a healthy body composition.* Use with
a reduced calorie diet and regular exercise program.
STRUCTURE AND FUNCTION
PhysioLogics Tonalin® CLA contains Conjugated Linoleic Acid (CLA), which exists
as several isomers of the essential polyunsaturated fatty acid Linoleic Acid.
Bioactive isomers include the cis-9, trans-11 isomer and trans-10, cis-12
isomer. Stereoisomers have seemingly different biological effects, making a
precise mechanism of action difficult to discern. CLA has been shown to promote
certain enzymes responsible for fatty acid betaoxidation and mobilization, such
as hormone sensitive lipoprotein lipase. Preliminary evidence suggests that CLA
promotes activation of peroxisome proliferatoractivated receptor alpha (PPARa),
a regulator of lipid homeostasis. Other mechanisms discussed in the scientific
literature include CLA's positive effects on total carnitine
palmitoyl-transferase activity, promoting fatty acyl CoA transfer from the
cytosol into the mitochondrial matrix. Uncoupling protein gene expression, as
evidenced in murine models, may also be partially responsible for the metabolic
effects of CLA at the level of ATP formation.*
CLINICAL EVIDENCE
- In a double-blinded trial, 60 male and female subjects who met the inclusion criteria of BMI>25 were randomized to receive one of four doses of Tonalin® CLA or matching placebo. Statistical analysis using Dunnett's test to make pair-wise comparisons of CLA vs. placebo revealed significant differences in body composition even at the lowest dose of 1.7g CLA per day. (Blankson et al, 2000)
- A double-blinded trial randomized 20 males and females to receive placebo or 1.8g per day of CLA from Tonalin®. Body composition was found to be significantly improved at 4, 8, and 12 week measures within CLA subjects and as compared to placebo subjects. (Thom et al, 2001)
SUMMARY
PhysioLogics Tonalin® CLA contains scientifically tested ingredients for
helping to inhibit triglyceride accumulation within adipocyte cells while
simultaneously supporting metabolism of all of the major macronutrients.*
Studies show that CLA can help support a healthy body composition.* Use with a
reduced calorie diet and regular exercise program.
SUGGESTED DOSAGE
For adults, take one (1) softgel three times daily, with a meal, or follow the
advice of a health care professional.
REFERENCES
Azain MJ, Hausman DB, Sisk MB, et al. Dietary conjugated linoleic acid reduces
rat adipose tissue cell size rather than cell number. J Nutr.
2000;130:1548-54.
Blankson H, Stakkestad JA, Fagertun H, et al. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr. 2000;130:2943-8.
Fremann D, Linseisen J, Wolfram G. Dietary conjugated linoleic acid (CLA) intake assessment and possible biomarkers of CLA intake in young women. Public Health Nutr. 2002;5:73-80.
Gaullier J, Halse J, H'ye K, et al. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr. 2004;79:1118-25.
Ghosh D, Bhattacharya B, Mukherjee B, et al. Role of chromium supplementation in Indians with type 2 diabetes mellitus. J Nutr Biochem. 2002;13:690-7.
Kaats GR, et al. Effects of chromium picolinate supplementation on body composition: a randomized, double-masked placebo controlled study. Current Thera Res. 1996;57:747-56.
Kamphuis MM, Lejeune MP, Saris WH, Westerterp- Plantenga MS. The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. Int J Obes Relat Metab Disord. 2003;27:840-7.
Kreider RB, Ferreira MP, Greenwood M, et al. Effects on conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength and selected hematological markers. J Strength Cond Res. 2002;16:325-34.
Lee NA, Reasner CA. Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM. Diabetes Care. 1994;17:1449-52.
Mougios V, Matsakas A, Petridou A, et al. Effect of supplementation with conjugated linoleic acid on human lipids and body fat. J Nutr Biochem. 2001;12:585-94.
Ohnuki K, Haramizu S, Oki K, et al. A single oral administration of conjugated linoleic acid enhanced energy metabolism in mice. Lipids. 2001;37:583-7.
Park Y, Storkson JM, Albright KJ, et al. Evidence that the trans-10 cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids. 1999;34:235-41.
Press RI, Geller J, Evans GW. The effect of chromium picolinate on serum cholesterol and apolipoprotein fractions in human subjects. West J Med. 1990;152:41-5.
Smedman A, Vessby B. Conjugated linoleic acid supplementation in humans® metabolic effects. Lipids. 2001;36:773-81.
Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res. 2001;29:392-6.
