Supports
Immune System Health*
Standardized to contain: 95% Curcuminoids***
HOW PATIENTS MAY BENEFIT
- For brain, antioxidant and immune system health*
PRODUCT DISCUSSION
PhysioLogics Turmeric Curcurmin combines the antioxidant benefits of whole
Turmeric root with Turmeric extract standardized for 95% Curcuminoids. Turmeric
(Curcuma longa) is a member of the ginger family and has been used as a food
additive throughout Asia and Central America for centuries. Its rhizome is rich
in the carotenoid Curcumin, which has been shown to possess significant
antioxidant properties.*
STRUCTURE AND FUNCTION
Turmeric contains beneficial plant-based antioxidants, including Curcurminoids,
that help fight cell-damaging free radicals.* Free radicals are unstable
molecules that can be produced from exposure to environmental factors like car
exhaust, cigarette smoke, and the body's own metabolic reactions. They may
contribute to oxidative stress and the premature aging of cells.* Turmeric and
Curcurmin support the immune system by helping stimulate the body's natural
defenses and may contribute to brain health.*
Curcumin has been shown to have bile-stimulating and liver-protectant activities in vitro. Curcuminoids exhibit their effects via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, reduction of the release of reactive oxygen species (ROS) by neutrophils, inhibition of AP-1 and NF-KappaB, and inactivation of cytokines such as TNF alpha and IL-1 beta.
CLINICAL EVIDENCE
- Fifteen subjects received between 440 and 2200 mg/day of curcuma extract (turmeric) for up to 4 months. The 3 subjects taking 440 mg of extract, which contained 36 mg of curcumin, experienced a significant (p<0.001) decrease in lymphocyte glutathione Stransferase activity by the 29th day. Lymphocyte GST increased in response to lipid peroxidation, lending support to the use of curcumin for antioxidant activity. (Sharma et al, 2001)
- In a recent population based cohort study, association between curry consumption and cognitive function was measured. Subjects who consumed more curry were reported to have higher cognitive functioning. The authors believe the positive benefits to be related to curcumin from turmeric as that is the principal ingredient of curry. (Ng et al, 2006)
SUMMARY
PhysioLogics Turmeric Curcurmin combines the benefits of whole Turmeric root
with Turmeric extract standardized for 95% Curcuminoids. Turmeric offers a
dietary means to support immune system, antioxidant and brain health.*
SUGGESTED DOSAGE
For adults, take one capsule daily, preferably with meal or follow the advice of
a health care professional.
REFERENCES
Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical
and clinical studies. Anticancer Res. 2003;23:363-98.
Ammon HP, et al. Mechanism of antiinflammatory actions of curcumine and boswellic acids. J Ethnopharmacol. 1993;38:113-9.
Araujo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz. 2001;96:723-8.
Cheng AL, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or premalignant lesions. Anticancer Res. 2001;21:2895-900.
Joe B, Vijaykumar M, Lokesh BR. Biological properties of curcumin-cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr. 2004;44:97-111.
Joshi J, Ghaisas S, Vaidya A, et al. Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers. J Assoc Physicians India. 2003;51:1055-60.
Kulkarni RR, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebocontrolled, cross-over study. J Ethnopharmacol. 1991;33:91-5.
Lin JK. Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by Curcumin. Arch Pharm Res. 2004;27:683-92.
Ng T, et al. Curry consumption and cognitive function in the elderly. Am J Epidemiol. 2006;164:898-906.
Ramirez-Bosca AA, et al. Antioxidant curcuma extracts decrease the blood lipid peroxide levels of human subjects. Age. 1995;18:167-9.
Rasyid A, Rahman AR, Jaalam K, Lelo A. Effect of different curcumin dosages on human gall bladder. Asia Pac J Clin Nutr. 2002;11:314-8.
Saxena A, Vikram NK. Role of selected Indian plants in management of type 2 diabetes: a review. J Altern Complement Med. 2004;10:369-78.
Scartezzini P, Speroni E. Review on some plants of Indian traditional medicine with antioxidant activity. J Ethnopharmacol. 2000;71:23-43.
Sharma RA, et al. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res. 2001;7:1894-900.
Thamlikitkul V, et al. Randomized double blind study of Curcuma domestica Val. for dyspepsia. J Med Assoc Thai. 1989;72:613-20.
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